Optogenetic inhibition of OFC disrupts inhibitory control

Dr. Brockett and colleagues recently published a new paper in eNeuro using optogenetics to disrupt stop-change task performance. We show that silencing the orbitofrontal cortex (OFC) reduces accuracy on difficult trials that require higher levels of inhibitory control. Silencing of the OFC also speeds response times on error trials, suggesting a role for the OFC in inhibitory control processes.